Viagra: How a Little Blue Pill Changed the World
Archived from the original on 14 August 2020. "Bears' Brandon Marshall says some NFL players use Viagra .. on the Field".
12.3 Pharmacokinetics
"Does marijuana use play a role in the recreational use of sildenafil?". Archived from the original on 26 January 2013. "Sildenafil accelerates reentrainment of circadian rhythms after advancing light schedules". Proceedings of the National Academy of Sciences of the United States of America. "Source: Roger Clemens, host of athletes pop Viagra to help onfield performance". Archived from the original on 5 March 2016. "Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: a history, analytical aspects and health risks". "Detection of sildenafil analogues in herbal products for erectile dysfunction". Archived from the original on 4 March 2016. ^ "FDA Warns Consumers About Dangerous Ingredients in "Dietary Supplements" Promoted for Sexual Enhancement". Archived from the original on 18 January 2017. ^ "Hidden Risks of Erectile Dysfunction 'Treatments' Sold Online". Archived from the original on 23 April 2019. ^ R.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Super Active | 100mg | 120 + 16 Pills | 198.37€ 188.92€ | |
| Viagra Original | 100mg | 64 + 4 Pills | 264.15€ 251.57€ | |
| Viagra Oral Jelly | 100mg | 90 + 8 Sachets | 258.02€ 245.73€ | |
| Viagra Soft Tabs | 100mg | 10 Pills | 36.93€ 35.17€ | |
| Viagra Professional | 100mg | 30 Pills | 88.92€ 84.69€ | |
| Viagra Original | 100mg | 92 + 4 Pills | 362.88€ 345.60€ | |
| Viagra Generic | 150mg | 10 Pills | 36.73€ 34.98€ | |
| Viagra Generic | 150mg | 30 + 2 Pills | 72.32€ 68.88€ | |
| Viagra Generic | 100mg | 120 + 6 Pills | 149.50€ 142.38€ | |
| Viagra Original | 100mg | 12 Pills | 72.54€ 69.09€ | |
| Viagra Oral Jelly | 100mg | 220 + 18 Sachets | 562.28€ 535.50€ | |
| Viagra Generic | 25mg | 20 Pills | 37.74€ 35.94€ | |
| Viagra Generic | 150mg | 270 + 10 Pills | 326.61€ 311.06€ | |
| Viagra Generic | 100mg | 360 + 10 Pills | 330.21€ 314.49€ | |
| Viagra Generic | 200mg | 10 Pills | 40.96€ 39.01€ | |
| Viagra Generic | 50mg | 20 Pills | 40.52€ 38.59€ | |
| Viagra Generic | 200mg | 90 + 6 Pills | 170.79€ 162.66€ |
Baselt, Disposition of Toxic Drugs and Chemicals in Man, 9th edition, Biomedical Publications, Seal Beach, CA, 2011, pp. Archived from the original (PDF) on 10 September 2011. "Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules". ^ a b Webb DJ, Freestone S, Allen MJ, Muirhead GJ (March 1999). "Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist". ^ Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA (May 1998). "Oral sildenafil in the treatment of erectile dysfunction. Archived from the original on 14 January 2012. "Onset and duration of action of sildenafil for the treatment of erectile dysfunction". ^ "Scientist who developed Viagra receives knighthood in New Year's Honours". Archived from the original on 14 January 2023. "Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond". Archived from the original on 26 September 2008. Our clinicians regularly offer patients the opportunity to take part in trials of new drugs and treatments.
What causes ED?
^ "Viagra 25mg film-coated tablets Summary of Product Characteristics (SmPC)". ^ "Viagra Connect 50 mg film-coated tablets Summary of Product Characteristics (SmPC)". Archived from the original on 13 August 2020. Archived from the original on 11 October 2020. Archived from the original on 11 November 2020.
Give yourself time for it to work
^ Nichols DJ, Muirhead GJ, Harness JA (6 March 2002). "Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality". The American Society of Health-System Pharmacists. Archived from the original on 23 April 2020. PDE-5 inhibitors appear to have significant but moderate efficacy in secondary [Raynaud's phenomenon].
What should I do if I miss a dose of sildenafil?
"Sublingual sildenafil in the treatment of erectile dysfunction: faster onset of action with less dose". "The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction". ^ "Drug Approval Package: Viagra (sildenafil citrate) NDA #020895". U.S. Food and Drug Administration (FDA). Morriston Hospital in Swansea, was the first in the world to trial Viagra! ^ Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, et al. "Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction".
- Viagra was the first oral medication approved for ED.
- It is sometimes used off-label for pulmonary hypertension.
- Adequate hydration is recommended when taking Viagra.
- Clinicians may adjust dosage based on individual response.
- Cialis and Levitra are alternative medications for ED.
- Follow a healthy diet and exercise to support sexual health.
"Sildenafil (Viagra), a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction". "Drug repositioning: identifying and developing new uses for existing drugs".
- Lifestyle factors like smoking cessation can improve erectile health.
- Psychological counseling can aid those with performance anxiety.
- Viagra should be stored out of reach of children.
- Side effects are usually mild but consult a doctor if severe.
- Combining Viagra with other vasodilators increases risk.
- Follow-up with your healthcare provider for ongoing management.
Archived from the original on 22 April 2019. Archived from the original on 10 June 2019. "Health situation in former communist bloc is dire, says Unicef". Archived from the original on 1 November 2012. ^ Gurevich M, Cormier N, Leedham U, Brown-Bowers A (August 2018). Sexuopharmaceutical use by men as prevention and proficiency". "Spreading the Word, but What Word is That? Viagra and Male Sexuality in Popular Culture". "A new view of women's sexual problems: Why new? Archived best viagra for men from the original on 3 January 2009. Archived from the original on 12 October 2008. "Sales of Impotence Drugs Fall, Defying Expectations". Archived from the original on 11 October 2007.
| Aspect | Effect | Scientific Evidence | Notes |
|---|---|---|---|
| Libido enhancement | Limited evidence | Not FDA-approved | Off-label considerations |
| Vaginal blood flow | Increased blood flow | Some studies show | More research needed |
| Satisfaction levels | Mixed results | Inconclusive | Subjective reports |
| Side effects in women | Similar to men, mild and rare | Limited data | Caution advised |
^ "Pfizer Courting More Controversy with Viagra 'Advergaming'". Archived from the original on 19 December 2019. Archived from the original on 6 May 2018. Archived from the original on 9 January 2009.
How do you take Viagra?
"Recreational use and misuse of phosphodiesterase 5 inhibitors". Archived from the original on 21 August 2016. "Sildenafil does not improve sexual function in men without erectile dysfunction but viagra medicine does reduce the postorgasmic refractory time". ^ McCambridge J, Mitcheson L, Hunt N, Winstock A (March 2006). "The rise of Viagra among British illicit drug users: 5-year survey data". Archived from the original on 22 February 2021.
| Aspect | Effect | Timeframe | Notes |
|---|---|---|---|
| Erection quality | Improved | After 30 min | Enhanced rigidity |
| Libido | Increased (indirect) | Within 1 hour | May vary among individuals |
| Perception of endurance | No direct effect | - | May feel more confident |
| Satisfaction levels | Higher reported rates | After sex | Dependent on other factors |
^ a b "Viagra now available over the counter without prescription in the UK". Archived from the original on 26 March 2021. Archived from the original on 8 December 2013. "The coming generics threat to Pfizer's Viagra brand just got scarier". Archived from the original on 9 September 2017. ^ "Viagra to go generic in 2017 according to Pfizer agreement".
- Viagra can be used with other ED medications but only under medical advice.
- It is not effective if there is no underlying erectile dysfunction.
- Lifestyle changes like exercise can enhance Viagra’s effectiveness.
- Viagra may cause a sudden drop in blood pressure in some cases.
- Men with certain health conditions should avoid using Viagra.
- Report any adverse reactions to your healthcare provider immediately.
Archived from the original on 1 December 2017. "Sex, Drugs and That Little Blue Pill".
Answer some quick questions to choose a treatment
"Interventions for preventing high altitude illness: Part 1. Archived from the original on 10 June 2017. ^ "FDA Updates Labeling for Viagra, Cialis and Levitra for Rare Post-Marketing Reports of Eye Problems" (Press release). Archived from the original on 22 October 2016. "Vision disorders and phosphodiesterase type 5 inhibitors: a review of the evidence to date".
Drug details
^ "FDA Announces Revisions to Labels for Cialis, Levitra and Viagra". "Drug interactions with phosphodiesterase-5 inhibitors used for the treatment of erectile dysfunction or pulmonary hypertension". "Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions". Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology/American Heart Association".
Erectile dysfunction
Journal of the American College of Cardiology. ^ "Viagra (Sildenafil Citrate): Side Effects, Interactions, Warning, Dosage & Uses". Archived from the original on 12 July 2018. "Young men add Viagra to their drug arsenal". Archived from the original on 4 September 2014. Archived from the original on 6 December 2017. "Why Pfizer Is About to Slash Viagra's Price in Half". Archived from the original on 7 December 2017. "Pfizer to lose patent of drug Viagra, Indian companies gear up with copycat versions: Pfizer's patent for the formulation of Viagra, used to treat impotence in men, ends in the US in 2020". Archived from the original on 17 April 2021. ^ "Set to conquer US, Indian 'Viagras' may give Pfizer a hard Time". Archived from the original on 22 December 2020. ^ a b "Pfizer Settles Viagra® Patent Litigation With Teva". "Lockout Supplements Issues Voluntary Nationwide Recall of Boner Bears Chocolate Syrup Due to Undeclared Sildenafil". Archived from the original on 19 November 2016. "Counterfeit Viagra, Cialis, Levitra: The Ultimate Guide". Archived from the original on 10 January 2017. "Online pharmacies suspected of counterfeit drug sales". ^ "Erectile Dysfunction Medication the Most Seized Drug During Global Crackdown, Interpol Says". ^ "Global illicit medicines targeted by INTERPOL operation". Archived from the original on 10 December 2023. ^ "Israeli-made AI exposes international fake Viagra network". ^ "Counterfeit Viagra Pills, Footwear, Belts, Car Emblems and Headphones Worth over $32 Million Seized at the LA/Long Beach Seaport U.S. Customs and Border Protection". Archived from the original on 12 October 2013. "Yes, There Is a Way to Get Generic Viagra". Archived from the original on 2 May 2016. "Pfizer Wins Viagra Patent Infringement Case Against Teva Pharmaceuticals".
| Condition | Caution Level | Explanation |
|---|---|---|
| Heart disease | High | Increased risk of cardiac events |
| Nitroglycerin medication | Absolute | Can cause dangerous drop in blood pressure |
| Liver impairment | Moderate | Altered drug metabolism |
| Recent stroke or heart attack | High | Risk of recurrence or complications |
Archived from the original on 11 January 2015. ^ "Pfizer Completes Transaction to Combine Its Upjohn Business with Mylan". Retrieved 17 June 2024 – via Business Wire. Archived from the original on 17 June 2024. "Viagra patent expires in June, says Brazilian court".
- Viagra has helped millions of men regain sexual confidence.
- The medication can be part of a broader approach to sexual health.
- Proper dosing is vital to avoid adverse effects.
- Always read the patient information leaflet thoroughly.
- Be aware of potential interactions with other prescriptions.
- Open communication with your doctor leads to better outcomes.
Archived from the original on 17 April 2012. ^ "Revatio patent ruled invalid for lack of sound prediction and obviousness".
Related questions
Archived from the original on 31 March 2021. Archived from the original on 12 August 2025. ^ "Sildenafil Drug Usage Statistics, United States, 2014 - 2023". "Generic Viagra: Two versions of sildenafil hit the market today". Archived from the original on 25 November 2018.
Viagra and foods
Archived from the original on 12 February 2022. "With Viagra Now Available Over-The-Counter In The U.K., Will The U.S. "Phosphodiesterase inhibitors for erectile dysfunction in patients with diabetes mellitus". "Strategies for managing sexual dysfunction induced by antidepressant medication". The Cochrane Database of Systematic Reviews (5) CD003382.
How can I get Viagra to work?
Archived from the original on 10 October 2020. "Efficacy and safety of sildenafil treatment in pulmonary arterial hypertension: a systematic review". Archived from the original on 29 August 2021. "Raynaud's phenomenon and digital ischaemia--pharmacologic approach and alternative treatment options". "Efficacy of Sildenafil on healthy humans in high‑altitude hypoxia at rest and during exercise: A meta‑analysis". Archived from the original on 3 March 2016. {{cite web}}: CS1 maint: deprecated archival service (link) ^ Teva Canada Ltd. v. Pfizer Canada Inc., 2012 SCC 60 at par. "Supreme Court ruling could lead to cheaper versions of Viagra". Archived from the original on 10 March 2013. "Canadian Supreme court rules Viagra patent invalid". Archived from the original on 11 November 2012. ^ "Viagra patent tossed out by Supreme Court: Decision allows generic versions of drug to be produced".